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Nanoscale drug carrier systems as therapeutics for targeted tumor therapy

Contact person: Ajmal Zarinwall

Project description:
The treatment of inoperable tumors on the basis of nanoscale drug carrier systems represents a promising alternative to currently established therapeutic methods such as chemotherapy. Targeted local applications of cytosolic therapeutics are made possible by the use of functionalized nanoparticles. However, only a very small part of the nanosystems is released from the endosomes after cellular uptake, while the majority is degraded lysosomally or ejected from the cell as part of a “recycling process” (A). Therefore, high systemic doses are required, which are associated with serious side effects. However, this natural barrier can be overcome by introducing a further component into the particle system, an endosomal escape enhancer (EnEsEn), and thus drastically reducing the necessary dose through a considerable increase in efficiency (B).

Within the framework of this project:

  • selectively functionalizes the surfaces of nanoparticles with therapeutic agents
  • cytotoxicity studies of the drug carrier systems performed
  • different formulation strategies to standardize the pharmacokinetics of the individual components
  •  

     
    Figure 1: Cellular uptake of nanoparticulate based tumor therapeutics and their ejection from the cell (A), or the overcoming of this by the use of a multi-component system, which results in apoptotic cell death by inactivation of the ribosomes. The carrier system is superparamagnetic iron oxide nanoparticles (SPION).

    Project partners:
    Institut für Laboratoriumsmedizin, Klinische Chemie und Pathobiochemie (Charité – Universitätsmedizin Berlin)


    Team Members

    Current Projects

    Quanomet, Junior Research Group “Nanofluidics & Particle Manipulation” more

    Processing of conjugated nanoparticle hybrid systems for use in biomedical diagnostics more

    Fractionation of Nanoparticles by Preparative Gel Electrophoresis subproject of the SPP 2045 more

    Advanced lithium-sulfur battery concepts for aviation (aero-LiS-SE) more

    Principles of nanoscale matrix additives for fibre composite more

    Nanoscale drug carrier systems as therapeutics for targeted tumor therapy more

    Small Angle X-ray Scattering as Metrological Instrument – A Correlation Study on the Optical Properties of Semiconductor Nanoparticles as ubiquitous Measure of Particle Size more

    Fractionation of Nanoparticles by Preparative Gel Electrophoresis more

    Thin nanoparticle films for cathode composites in all solid state batteries more

    ElektroBak – Innovative Materials and Concepts for Microbial Electrochemical Systems more

    Characteristics of a nanoparticulate coating based on the process chain more

    Finished Projects
    Synthesis and processing of tailored AZO nanocrystals more

    Preparation of multifunctional nanocomposite thin films made of nanosized building blocks more

    Process technology of the synthesis of metal oxide nanoparticles by nonaqueous sol gel methods more

    Biocompatible iron-oxide nanoparticles for the in-situ magnetic separation of bioproducts more

    Small-Molecule Stabilization of ITO Nanoparticles more

    AiF – CleanCoat: Development of transparent, photocatalytically active coatings on polymer substrates with long-term stability more

    Protein purification with functionalized magnetic nanoparticles more