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Processing of conjugated nanoparticle hybrid systems for use in biomedical diagnostics

Contact person: Viktor Maurer

Project description:
A measurement principle that has caught a lot of attention in recent years due to the extremely high analytical sensitivity is called surface-enhanced Raman spectroscopy (SERS). SERS is based on plasmonic surfaces such as gold nanoparticles and leads to Raman signals which are up to 1010-fold higher than in conventional Raman spectroscopy. In this project, several multifunctional nanoparticle systems are synthesized and used for diagnostic SERS-based ex-vivo and in-vitro applications.

Figure: (a) Antibody-functionalized iron oxide and gold nanoparticles for magnetic purification and subsequent detection of tau-protein, (b) SERS-active hybrid nanoparticle system consisting of gold-coated iron-platinum nanoparticles encapsulated in an organic carrier particle and used for a highly sensitive in-vitro diagnostic.

Objectives and tasks of the iPAT:

  • Establishment of different hybrid nanoparticle systems with tailored properties for SERS-based diagnostics
  • Characterization of the particle synthesis and functionalization as well as acquisition of the essential process parameters to ensure the important product properties
  • Diagnostic and therapeutic ex-vivo/in-vitro applications of the hybrid nanoparticles

    Cooperation partner:

    – Physikalisch-Technische Bundesanstalt
    – Medizinische Hochschule Hannover

    Team Members

    Current Projects
    Synthesis, self-assembly and printing of hard-magnetic nanoparticles more

    Quanomet, Junior Research Group “Nanofluidics & Particle Manipulation” more

    Processing of conjugated nanoparticle hybrid systems for use in biomedical diagnostics more

    Fractionation of Nanoparticles by Preparative Gel Electrophoresis subproject of the SPP 2045 more

    Advanced lithium-sulfur battery concepts for aviation (aero-LiS-SE) more

    Principles of nanoscale matrix additives for fibre composite more

    Nanoscale drug carrier systems as therapeutics for targeted tumor therapy more

    Small Angle X-ray Scattering as Metrological Instrument – A Correlation Study on the Optical Properties of Semiconductor Nanoparticles as ubiquitous Measure of Particle Size more

    Fractionation of Nanoparticles by Preparative Gel Electrophoresis more

    Thin nanoparticle films for cathode composites in all solid state batteries more

    ElektroBak – Innovative Materials and Concepts for Microbial Electrochemical Systems more

    Characteristics of a nanoparticulate coating based on the process chain more

    Finished Projects
    Synthesis and processing of tailored AZO nanocrystals more

    Preparation of multifunctional nanocomposite thin films made of nanosized building blocks more

    Process technology of the synthesis of metal oxide nanoparticles by nonaqueous sol gel methods more

    Biocompatible iron-oxide nanoparticles for the in-situ magnetic separation of bioproducts more

    Small-Molecule Stabilization of ITO Nanoparticles more

    AiF – CleanCoat: Development of transparent, photocatalytically active coatings on polymer substrates with long-term stability more

    Protein purification with functionalized magnetic nanoparticles more