• Deutsch
  • English

Stabilization and Functionalization of Nanoparticles

Due to their extremely high specific surface area, nanoparticles strongly tend to agglomerate. For many applications it is however essential to handle them in individual form, often as single particles dispersed in a liquid medium. Therefore, the stabilization of nanoparticles against agglomeration via a controlled chemical modification of the particle surface is a main research focus of our group. Especially the use of small organic molecules, termed ligands, is explored, as highly stable dispersions with minimum amounts of the organic stabilizer can be obtained.

Beyond the concept of stabilization, it is also possible to specifically bind molecules to the particle surface to tailor the particle properties and enable novel functions and properties. For example, antibodies can selectively be anchored to magnetic nanoparticles, which is investigated within the framework of the Collaborative Research Center SFB 578. Even the optical properties of nanoparticles can be altered by functionalization, as is shown in the image.

Functionalized TiO2nanoparticles (a) as dried powder and (b) in dispersion after in situ-functionalization with dopamine; (c) as dried powder and (d) in dispersion after in situ-functionalization with glycine. Right: schematic of a dopamine-stabilized nanoparticle.


[1] I.-C. Masthoff, F. David, C. Wittmann, G. Garnweitner, “Functionalization of magnetic nanoparticles with high-binding capacity for affinity separation of therapeutic proteins”, Journal of Nanoparticle Research 2014, 16, Art. No. 2164. Abstract
[2] Grote C, Cheema TA, Garnweitner G. “Comparative study of ligand binding during the postsynthetic stabilization of metal oxide nanoparticles, Langmuir. 2012, 28, 14395-14404. Abstract
[3] C. Grote, K. J. Chiad, D. Vollmer, G. Garnweitner, “Unspecific ligand binding yielding stable colloidal ITO- nanoparticle dispersions”, Chemical Communications 2012, 48, 1464-1466. Abstract.
[4] G. Garnweitner, “Small molecule stabilization: A novel concept for the stabilization of small inorganic nanoparticles”, in: L. Segewicz and M. Petrowsky (Eds.), “Polymer Aging, Stabilizers and Amphiphilic Block Copolymers”, Nova Science Publishers, 2010.
[5] G. Garnweitner, H. O. Ghareeb, C. Grote, “Small-molecule in situ stabilization of TiO2 nanoparticles for the facile preparation of stable colloidal dispersions”, Colloids and Surfaces Part A: Physicochemical and Engineering Aspects 2010, 372, 41-47.
[6] G. Garnweitner, L. M. Goldenberg, O. V. Sakhno, M. Antonietti, M. Niederberger, J. Stumpe, “Large-scale synthesis of organophilic zirconia nanoparticles and their application in organic-inorganic nanocomposites for efficient volume holography”, Small 2007, 3, 1626-1632.

Team Members

Current Projects
Synthesis, self-assembly and printing of hard-magnetic nanoparticles more

Quanomet, Junior Research Group “Nanofluidics & Particle Manipulation” more

Processing of conjugated nanoparticle hybrid systems for use in biomedical diagnostics more

Fractionation of Nanoparticles by Preparative Gel Electrophoresis subproject of the SPP 2045 more

Advanced lithium-sulfur battery concepts for aviation (aero-LiS-SE) more

Principles of nanoscale matrix additives for fibre composite more

Nanoscale drug carrier systems as therapeutics for targeted tumor therapy more

Small Angle X-ray Scattering as Metrological Instrument – A Correlation Study on the Optical Properties of Semiconductor Nanoparticles as ubiquitous Measure of Particle Size more

Fractionation of Nanoparticles by Preparative Gel Electrophoresis more

Thin nanoparticle films for cathode composites in all solid state batteries more

ElektroBak – Innovative Materials and Concepts for Microbial Electrochemical Systems more

Characteristics of a nanoparticulate coating based on the process chain more

Finished Projects
Synthesis and processing of tailored AZO nanocrystals more

Preparation of multifunctional nanocomposite thin films made of nanosized building blocks more

Process technology of the synthesis of metal oxide nanoparticles by nonaqueous sol gel methods more

Biocompatible iron-oxide nanoparticles for the in-situ magnetic separation of bioproducts more

Small-Molecule Stabilization of ITO Nanoparticles more

AiF – CleanCoat: Development of transparent, photocatalytically active coatings on polymer substrates with long-term stability more

Protein purification with functionalized magnetic nanoparticles more