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Pharma and Bio Particle Technology

Team Leader: Dr.-Ing. Ingo Kampen

The research group Biological and Pharmaceutical Particle Technology merges natural sciences and engineering to address biological, biotechnological as well as pharmaceutical topics. This interdisciplinary approach admits the application of engineering methods to biological and pharmaceutical components. For Example: Mechanical parameters, usually confined to application in engineering, can thus be assigned to microbial cell walls.
For the performance of these interdisciplinary research tasks the institute owns appropriate laboratories and advanced level equipment. A great part of the measuring problems are executed with an atomic force microscope and a nanoindenter. These devices enable the manipulation of particles and layers with an accuracy of less than one nanometer. At present, microbial cells and fungal hyphae as well as biofilms are the preferred research subjects. Besides the mechanical properties adhesive forces between biological particles are investigated.

 

 

Figures: left: bursted S. cerevisiae cell; middle: global (nanoindenter) und local (AFM) stressing; right: AFM image of an E. coli cell

Furthermore, this workgroup investigates the environmental fate of nanoparticles. To this end, the interaction with soil components and the influence on edaphic microorganisms are studied.


Team Members

Current Projects

Investigation and modeling of mechanical and surface-induced stress of pelleted filamentous microorganisms more

Micromechanical Properties of Filamentous Fungi more

Untersuchung der zellmechanischen Eigenschaften einzelner Mikroorganismen more

Finished Projects

Behavior of UV-absorbing metal oxide nanoparticles in porous media and their influence on soil bacteria more

Biofilm Mechanics more

Einfluss der Zellaufschlussmethode auf die Expanded Bed Chromatographie mehr