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Nanomilling of active pharmaceutical ingredients (API) in stirred media mills

Contact Person: André Bitterlich

Nanoparticles are already used in products of daily life like paint or sunscreen to improve performance. In pharmaceutical industries they start to play an important role as well. Due to the nanoparticles’ high surface area-to-volume ratio, the solubility of non- or hardly soluble products is strongly improved. That leads to an increased bioavailability which allows the use of a broad variety of new API in pharmacological applications.
Until now, nanomilling has been mainly investigated for inorganic systems. The applicability of this knowledge on pharmaceutical (organic) particles has to be investigated.

Within the framework of this project, the influence of operating parameters and stabilizers on the comminution of API will be analysed. Especially the determination of maximum product fineness and the minimization of product contamination by wear of grinding media will be an important part of the research. The influence of operating parameters and stabilizers on product morphology will be studied as well.
By using micromechanical measuring techniques, specific properties of the nanoparticles like elastic and plastic deformation will be analysed. The objective is to find a dependency between these parameters and the particles fracture behaviour.
Furthermore, an important part of this project is the establishment of a procedure for systematic stabilizer selection.

Fig. 1 Rotor and Grinding chamber of SMM  Fig. 2 Ground Product

Publications:
A. Bitterlich, C. Komoß, D. Steiner, H. Bunjes, A. Kwade (2011) Nanomilling of Naproxen in Stirred Media Mills, 7th International Symposium Fine Grinding and Dispersing, Braunschweig, Germany, Conf. Proc., 28-35 (ISBN 13 978-3-86844-368-4)


Team Members

Current Projects

Future Grinding Technologies more

Charge-based selective separation of submicron particles from grinding processes more

Silicon Graphite goes Industry more

Ultra-fine grinding of multi-component systems in stirred media mills more

Increase of the energy efficiency by controlling the flow properties and minimizing the agglomeration in dry fine grinding processes more

Stress events in planetary ball mills and their application on scaling and mill-changing behaviour more

Nanogrinding of organic and inorganic materials more

Nanogrinding of pharmaceutical ingredients in stirred media mills more

Finished Projects