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Thesis Pharma- and Bioparticletechnology

Investigation on the process chain of pharmaceutical powders to tablets

During this thesis, the process chain during the mixing, granulation and tableting of different pharmaceutical formulations should be investigated. Process and formulation parameters during the granulation and tableting should be systematically varied to identify critical steps which determine the final product properties.

Determination of required mechanical properties of tablets

During this thesis, the influence of different types of stress (e.g. impact and tensile stress) on the mechanical strength of pharmaceutical tablets with varying geometries should be investigated. Additonally, by using typical active pharmaceutical ingredients and excipients, the impact of different deformation behaviour should be characterised

Analysis of the strain rate sensitivity of pharmaceutical powders

During this thesis, different active pharmaceutical ingredients and excipients should be compacted with varying compression velocities. The results should be used to develope mechanistic models to describe the influence of compression speed on the densification and compaction behaviour of pharmaceutical powders

Targeted surface modification of micro particles for the optimization of biotechnical cultivations

Filamentous microorganisms are widely used production systems in the industrial biotechnology. This project investigates the influence of microparticles on the production of an active pharmaceutical ingredient. mehr

Performance and validation of CFD-DEM-simulations of stirred and shaken bioreactors

The aim of this project is to investigate the correlation of the morphology and the productivity for filamentous microorganisms. Early results showed an increased concentration of the antibiotic product due to the addition of macro particles to the cultivation media. mehr

Development of a small scale drying approach for API-nanosuspensions

The reduction of the particle size into the submicronic range is an established method to increase bioavail ability of poorly water solubl e acti ve pharmaceutical ingredients (AP Is). Despite thei r advantages, nanosuspensions exhibit certai n disadvantages making thei r conversion into the solid state preferred. Thereby, drying processes of API-nanosuspensions are not completely understood yet limiting a specific process and formulation design. mehr

Influence of process- and formulation- parameters during drying of API- nanosuspensions

The reduction of the particle size into the submicronic range is an established method to increase bioavailabilities of poorly water soluble active pharmaceutical ingredients (APIs). Despite their advantages, nanosuspensions exhibit certain disadvantages concerning their physical und chemical stability. Therefore, a conversion of the suspensions into the solid state by adequate drying techniques is prefered. mehr

Lehre_SA_SGT_IsK_1215 Tableting: Transferability from a compaction simulator to a rotary tablet press

Tablets have an estimated market value of 300 billion $/year and are therefore, one of the financial most important dosage form in the pharmaceutical industry. The formulation and process development is commonly carried out empirically and therefore, is very time- and material-consuming. In recent years, compaction simulators are used for the simulation of the compaction process in rotary tablet presses. The high resolution of the instrumentation allows a more detailed understanding of process. mehr

Team Members

Current Projects

Investigation and modeling of mechanical and surface-induced stress of pelleted filamentous microorganisms more

Micromechanical Properties of Filamentous Fungi more

Untersuchung der zellmechanischen Eigenschaften einzelner Mikroorganismen more

Finished Projects

T-MAPPP – Simulation of breakage and abrasion of granules and tablets more

Behavior of UV-absorbing metal oxide nanoparticles in porous media and their influence on soil bacteria more

Biofilm Mechanics more

Einfluss der Zellaufschlussmethode auf die Expanded Bed Chromatographie mehr